Publications

2017

Wottawa, M., Naas, S., Böttger, J., van Belle, G.J., Möbius, W., Revelo, N.H., Heidenreich, D., von Ahlen, M., Zieseniss, A., Kröhnert, K., Lutz, S., Lenz, C., Urlaub, H., Rizzoli, S.O., Katschinski, D.M. Hypoxia-stimulated membrane trafficking requires T-Plastin. Acta Physiol (Oxf). 2017 Sep;221(1):59-73.

Guentsch, A., Beneke, A., Swain, L., Farhat, K., Nagarajan, S., Wielockx, B., Raithatha, K., Dudek, J., Rehling, P., Zieseniss, A., Jatho, A., Chong, M., Santos, C.X., Shah, A.M., Katschinski, D.M. PHD2 is a regulator for gly-colytic reprogramming in macrophages. Mol Cell Biol. 2016 Dec 19;37(1). pii: e00236-16. Print 2017 Jan 1.

2016

Liu, X., Qi, J., Xu, X., Zeisberg, M., Guan, K., Zeisberg, E.M. Differentiation of functional endothelial cells from human induced pluripotent stem cells: A novel, highly efficient and cost effective method. Differentiation. 2016 Oct - Nov; 92(4):225-236.

Swain, L., Kesemeyer, A., Meyer-Roxlau, S., Vettel, C., Zieseniss, A., Güntsch, A., Jatho, A., Becker, A., Nanadikar, M.S., Morgan, B., Dennerlein, S., Shah, A.M., El-Armouche, A., Nikolaev, V.O., Katschinski, D.M. Redox Imaging Using Cardiac Myocyte Specific Transgenic Biosensor Mice. Circ Res. 2016 Oct 14;119(9):1004-1016.

Sirker, A., Murdoch, C.E., Protti, A., Sawyer, G.J., Santos, C.X., Martin, D., Zhang, X., Brewer, A.C., Zhang, M., Shah, A.M. Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction. J Mol Cell Cardiol. 2016 Sep;98:11-17.

Puhl, S.L., Weeks, K.L., Ranieri, A., Avkiran, M. Assessing structural and functional responses of murine hearts to acute and sustained β-adrenergic stimulation in vivo. J Pharmacol Toxicol Methods. 2016 May-Jun;79:60-71.

Mohamed, B.A., Asif, A.R., Schnelle, M., Qasim, M., Khadjeh, S., Lbik, D., Schott, P., Hasenfuss, G., Toischer, K. Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy. J Transl Med. 2016 May 27; 14(1):149.

Santos, C.X., Raza, S., Shah, A.M. Redox signaling in the cardiomyocyte: From physiology to failure. Int J Biochem Cell Biol. 2016 May;74:145-51.

Mohamed, B.A., Schnelle, M., Khadjeh, S., Lbik, D., Herwig, M., Linke, W.A., Hasenfuss, G., Toischer, K. Molecular and structural transition mechanisms in long-term volume overload. Eur J Heart Fail. 2016 Apr; 18(4):362-71.

Mistry, R.K., Murray, T.V., Prysyazhna, O., Martin, D., Burgoyne, J.R., Santos, C., Eaton, P., Shah, A.M., Brewer, A.C. Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling. J Biol Chem. 2016 Jan 22;291(4):1774-88.

Korthout, T., Emanuelli, G., Hutchins, J.R. Extracting order from heterogeneity: A report on the EpiGeneSys workshop "Single Cell Epigenetics" in Montpellier. June 11-12, 2016. Bioessays. Jan;38(1):4-7.

Santos, C.X., Hafstad, A.D., Beretta, M., Zhang, M., Molenaar, C., Kopec, J., Fotinou, D., Murray, T.V., Cobb, A.M., Martin, D., Zeh Silva, M., Anilkumar, N., Schröder, K., Shanahan, C.M., Brewer, A.C., Brandes, R.P., Blanc, E., Parsons, M., Belousov, V., Cammack, R., Hider, R.C., Steiner, R.A., Shah, A.M. Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling. EMBO J. 2016 Feb 1;35(3):319-34.

Protti, A., Mongue-Din, H., Mylonas, K.J., Sirker, A., Sağ, C.M., Swim, M.M., Maier, L., Sawyer, G., Dong, X., Botnar, R., Salisbury, J., Gray, G.A., Shah, A.M. Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction. J Mol Cell Cardiol. 2016 Jan;90:120-8.

2015

Siegert, I., Schödel, J., Nairz, M., Schatz, V., Dettmer, K., Dick, C., Kalucka, J., Franke, K., Ehrenschwender, M., Schley, G., Beneke, A., Sutter, J., Moll, M., Hellerbrand, C., Wielockx, B., Katschinski, D.M., Lang, R., Galy, B., Hentze, M.W., Koivunen, P., Oefner, P.J., Bogdan, C., Weiss, G., Willam, C., Jantsch, J. Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen. Cell Rep.2015 Dec 15; 13(10), 2048-2055.

Hartmann, S., Ridley, A.J., Lutz, S. The function of Rho-dependent kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease Front. Pharmacol. 2015 Nov 20;6:276.

Staab, J., Riebeling, T., Koch, V., Herrmann-Lingen, C., Meyer, T. The two interfaces of the STAT1 N-terminus exhibit opposite functions in IFNγ-regulated gene expression. Mol Immunol. 2015 Oct;67(2 Pt B):596-606.

Jatho, A., Hartmann, S., Kittana, N., Mügge, F., Wuertz, C.M., Tiburcy, M., Zimmermann, W.-H., Katschinski, D.M., Lutz, S. RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes. PLoS One. 2015 Oct 8;10(10):e0137519.

Vogler, M., Zieseniss, A., Hesse, A.R., Levent, E., Tiburcy, M., Heinze, E., Burzlaff, N., Schley, G., Eckardt, K.U., Willam, C., Katschinski, D.M. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch. 2015 Oct;467(10):2141-9.

Ongherth, A., Pasch, S., Wuertz, C.M., Nowak K., Kittana, N., Weis, C.A., Jatho, A., Vettel, C., Tiburcy, M., Toischer, K., Hasenfuss, G., Zimmermann, W.-H., Wieland, T., Lutz, S. p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. J Mol Cell Cardiol. 2015 Sep 21;88:39-54

Johnston, A.S., Lehnart, S.E., Burgoyne, J.R. Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII. Front Pharmacol. 2015 Aug 10;6:166.

Czepluch, F.S., Vogler, M., Kuschicke, H., Meier, J., Gogiraju, R., Katschinski, D.M., Riggert, J., Hasenfuss, G., Schäfer, K. Circulating endothelial cells expressing the angiogenic transcription factor Krüppel-like factor 4 are decreased in patients with coronary artery disease. Microcirculation. 2015 Jul 27.

Zhang, M., Prosser, B.L., Bamboye, M.A., Gondim, A.N., Santos, C.X., Martin, D., Ghigo, A., Perino, A., Brewer, A.C., Ward, C.W., Hirsch, E., Lederer, W.J., Shah, A.M. Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation. J Am Coll Cardiol. 2015 Jul 21;66(3):261-72.

Xu, X., Tan, X., Tampe, B., Sanchez, E., Zeisberg, M., Zeisberg, E.M. Snail is a Direct Target of HIF1α in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells. J Biol Chem. 2015 Jul 3;290(27):16653-64.

Fischer, T.H., Herting, J., Mason, F.E., Hartmann, N., Watanabe, S., Nikolaev, V.O., Sprenger, J.U., Fan, P., Yao, L., Popov, A.F., Danner, B.C., Schöndube, F., Belardinelli, L., Hasenfuss, G., Maier, L.S., Sossalla, S. Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII. Cardiovasc Res. 2015 Jul 1;107(1):184-96.

Book chapter: Bastuğ, Z., Nikolaev, V.O. Cyclic Nucleotide Signaling (Methods in Signal Transduction Series) edited by Xiaodong Cheng., May 12, 2015 by CRC Press. ISBN 9781482235562.

Sprenger. J.U., Perera, R.K., Steinbrecher, J.H., Lehnart, S.E., Maier, L.S., Hasenfuss, G., Nikolaev, V.O. In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease. Nat Commun. 2015 Apr 28;6:6965.

Perera, R.K., Sprenger, J.U., Steinbrecher, J.H., Hübscher, D., Lehnart, S.E., Abesser, M., Schuh, K., El-Armouche, A., Nikolaev, V.O. Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy. Circ Res. 2015 Apr 10;116(8):1304-11.

Murray, T.V., Smyrnias, I., Schnelle, M., Mistry, R.K., Zhang, M., Beretta, M., Martin, D., Anilkumar, N., de Silva, S.M., Shah, A.M., Brewer, A.C. Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription. J Mol Cell Cardiol. 2015 Feb;79:54-68.

2014

Riebeling, T., Staab, J., Herrmann-Lingen, C., Meyer, T. DNA binding reduces the dissociation rate of STAT1 dimers and impairs the interdimeric exchange of protomers. BMC Biochem. 2014 Dec 20;15:28.

Izarra, A., Moscoso, I., Levent, E., Cañón, S., Cerrada, I., Díez-Juan, A., Blanca, V., Núñez-Gil, I.J., Valiente, I., Ruíz-Sauri, A., Sepúlveda, P., Tiburcy, M., Zimmermann, W.-H., Bernad, A. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction. Stem Cell Reports. 2014 Dec 9;3(6):1029-42.

Sağ, C.M., Mallwitz, A., Wagner, S., Hartmann, N., Schotola, H., Fischer, T.H., Ungeheuer, N., Herting, J., Shah, A.M., Maier, L.S., Sossalla, S., Unsöld, B. Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner. J Mol Cell Cardiol. 2014 Nov; 76:94-105.

Wagner, S., Dantz, C., Flebbe, H., Azizian, A., Sağ, C.M., Engels, S., Möllencamp, J., Dybkova, N., Islam, T., Shah, A.M., Maier, L.S. NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII. J Mol Cell Cardiol. 2014 Oct;75:206-15.

Swain, L., Wottawa, M., Hillemann, A., Beneke, A., Odagiri, H., Terada, K,, Endo, M., Oike, Y., Farhat, K., Katschinski, D.M. Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions. J Leukoc Biol. 2014 Sep;96(3):365-75.

Sağ, C.M., Santos, C.X., Shah, A.M. Redox regulation of cardiac hypertrophy. J Mol Cell Cardiol. 2014 Aug;73:103-11.

Nussbeck, S.Y., Weil, P., Menzel, J., Marzec, B., Lorberg, K., Schwappach, B. The laboratory notebook in the 21st century: The electronic laboratory notebook would enhance good scientific practice and increase research productivity. EMBO Rep. 2014 Jun;15(6):631-4.

Puente, B.N., Kimura, W., Muralidhar, S.A., Moon, J., Amatruda, J.F., Phelps, K.L., Grinsfelder, D., Rothermel, B.A., Chen, R., Garcia, J.A., Santos, C.X., Thet, S., Mori, E., Kinter, M.T., Rindler, P.M., Zacchigna, S., Mukherjee, S., Chen, D.J., Mahmoud, A.I., Giacca, M., Rabinovitch, P.S., Aroumougame, A., Shah, A.M., Szweda, L.I., Sadek, H.A. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell.2014 Apr 24;157(3):565-79.

Vettel C., Lämmle, S., Ewens, S., Cervirgen, C., Emons, J., Ongherth, A., Dewenter, M., Lindner, D., Westermann, D., Nikolaev, V.O., Lutz, S., Zimmermann, W.-H., El-Armouche, A. PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1246-52.

Götz, K.R., Sprenger, J.U., Perera, R.K., Steinbrecher, J.H., Lehnart, S.E., Kuhn, M., Gorelik, J., Balligand, J.L., Nikolaev, V.O. Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes. Circ Res. 2014 Apr 11;114(8):1235-45.

Koch, R., Demant, M., Aung, T., Diering, N., Cicholas, A., Chapuy, B., Wenzel, D., Lahmann, M., Güntsch, A., Kiecke, C., Becker, S., Hupfeld, T., Venkataramani, V., Ziepert, M., Opitz, L., Klapper, W., Trümper, L., Wulf, G.G. Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma. Blood. 2014 Apr 3;123(14):2189-98.

Weber, M., Heta, E., Moreira, R., Gesche, V.N.,Schermer, T., Frese, J., Jockenhoevel, S., Mela, P. Tissue-engineered fibrin-based heart valve with a tubular leaflet design. Tissue Eng Part C Methods. 2014 Apr;20(4):265-75.

Longman, M.R., Ranieri, A., Avkiran, M., Snabaitis A.K. Regulation of PP2AC Carboxylmethylation and Cellular Localisation by Inhibitory Class G-Protein Coupled Receptors In Cardiomyocytes. PLoS One. 2014 Jan 27;9(1):e86234.

Santos, C.X., Nabeebaccus, A.A., Shah, A.M., Camargo, L.L., Filho, S.V., Lopes, L.R. Endoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: potential role in hypertension. Antioxid Redox Signal. 2014 Jan 1;20(1):121-34. doi: 10.1089/ars.2013.5262. Epub 2013 May 1.

Hesse, A.R., Levent, E., Zieseniss, A., Tiburcy, M., Zimmermann, W.-H., Katschinski, D.M. Lights on for HIF-1α: genetically enhanced mouse cardiomyocytes for heart tissue imaging. Cell Physiol Biochem. 2014;34(2):455-62.

2013

Burgoyne, J.R., Oviosu, O., Eaton, P. The PEG-switch assay: a fast semi-quantitative method to determine protein reversible cysteine oxidation. J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):297-301.

Sağ, C.M., Wolff, H.A., Neumann, K., Opiela, M.K., Zhang, J., Steuer, F., Sowa, T., Gupta, S., Schirmer, M., Hünlich, M., Rave-Fränk, M., Hess, C.F., Anderson, M.E., Shah, A.M., Christiansen, H., Maier, L.S. Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII. Basic Res Cardiol. 2013 Nov;108(6):385.

Abonnenc, M., Nabeebaccus, A.A., Mayr, U., Barallobre-Barreiro, J., Dong, X., Cuello, F., Sur, S., Drozdov, I., Langley, S.R., Lu, R., Stathopoulou, K., Didangelos, A., Yin, X., Zimmermann, W.-H., Shah, A.M., Zampetaki, A., Mayr, M. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ Res. 2013 Oct 25;113(10):1138-47.

Toischer, K. Hartmann, N. Wagner, S. Fischer, TH. Herting, J. Danner, BC. Sağ, C.M., Hund, TJ. Mohler, PJ. Belardinelli, L. Hasenfuss, G. Maier, LS. Sossalla, S. Role of late sodium current as a potential arrhythmo-genic mechanism in the progression of pressure-induced heart disease. J Mol Cell Cardiol. 2013 Aug;61:111-22. doi: 10.1016/j.yjmcc.2013.03.021. Epub 2013 Apr 6.

Vogler, M., Vogel, S., Krull, S., Farhat, K., Leisering, P., Lutz, S., Wuertz, C.M., Katschinski, D.M., Zieseniss, A. Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution. PLoS One. 2013 Jul 18;8(7):e69128.

Wottawa, M., Leisering, P., Ahlen, M v., Schnelle, M., Vogel, S., Malz, C., Bordoli, M.R., Camenisch, G., Hesse, A., Napp, J., Alves, F., Kristiansen, G., Farhat, K., Katschinski, D.M. Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processing. Int J Cancer. 2013 Jun 15;132(12):2787-98.

Neef, S., Sağ, C.M., Daut, M., Bäumer, H., Grefe, C., El-Armouche, A., DeSantiago, J., Pereira, L., Bers, D.M., Backs, J., Maier, L.S. While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice. J Mol Cell Cardiol. 2013 Jun;59:107-16.

Sukumar, P., Viswambharan, H., Imrie, H., Cubbon, R.M., Yuldasheva, N., Gage, M., Galloway, S., Skromna, A., Kandavelu, P., Santos, C.X., Gatenby, V.K., Smith, J., Beech, D.J., Wheatcroft, S.B., Channon, K.M., Shah, A.M., Kearney, M.T. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes. 2013 Jun;62(6):2130-4.

Karamariti, E., Margariti, A., Winkler, B., Wang, X., Hong, X., Baban, D., Ragoussis, J., Huang, Y., Han, J.D., Wong, M.M., Sağ, C.M., Shah, A.M., Hu, Y., Xu, Q. Smooth muscle cells differentiated from reprogrammed embryonic lung fibroblasts through DKK3 signaling are potent for tissue engineering of vascular grafts. Circ Res. 2013 May 24;112(11):1433-43.

Perera, R.K., Nikolaev, V.O. Compartmentation of cAMP signalling in cardiomyocytes in health and disease. Acta Physiol (Oxf). 2013 Apr;207(4):650-62.

Sprenger, J.U., Nikolaev, V.O. Biophysical techniques for detection of cAMP and cGMP in living cells. Int J Mol Sci. 2013 Apr 12;14(4):8025-46.

Anilkumar, N., San Jose, G., Sawyer, I., Santos, C.X., Sand, C., Brewer, A.C., Warren, D., Shah, A.M. A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):e104-12.

Avan, A., Quint, K., Nicolini, F., Funel, N., Frampton, A.E., Maftouh, M., Pelliccioni, S., Schuurhuis, G.J., Peters, G.J., Giovannetti, E. Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.