Publications

2022

Stejerean-Todoran I, Zimmermann K, Gibhardt CS, Vultur A, Ickes C, Shannan B, Bonilla Del Rio Z, Wölling A, Cappello S, Sung HM, Shumanska M, Zhang X, Nanadikar M, Latif MU, Wittek A, Lange F, Waters A, Brafford P, Wilting J, Urlaub H, Katschinski DM, Rehling P, Lenz C, Jakobs S, Ellenrieder V, Roesch A, Schön MP, Herlyn M, Stanisz H and Bogeski I. MCU controls melanoma progression through a redox-controlled phenotype switch. EMBO Rep. 2022 Sep 26, 10.15252/embr.202254746:e54746 DOI: 10.15252/embr.202254746.

 

Seibertz F, Rapedius M, Fakuade FE, Tomsits P, Liutkute A, Cyganek L, Becker N, Majumder R, Clauß S, Fertig N and Voigt N. A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes. Commun Biol. 2022 Sep 5;5:969 DOI: 10.1038/s42003-022-03871-2.

Stejerean-Todoran I, Gimotty PA, Watters A, Brafford P, Krepler C, Godok T, Li H, Bonilla Del Rio Z, Zieseniss A, Katschinski DM, Sertel SM, Rizzoli SO, Garman B, Nathanson KL, Xu X, Chen Q, Oswald JH, Lotem M, Mills GB, Davies MA, Schön MP, Bogeski I, Herlyn M and Vultur A. A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells. Neuro Oncol. 2022 Sep 2;noac212 DOI: 10.1093/neuonc/noac212.

 

Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N and Fertig N. There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments. Front Mol Neurosci. 2022 Aug 22;15:982316 DOI: 10.3389/fnmol.2022.982316.

Santos GL, DeGrave AN, Rehman A, Al Disi S, Xhaxho K, Schröder H, Bao G, Meyer T, Tiburcy M, Dworatzek E, Zimmermann WH and Lutz S. Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues. Biomater Adv. 2022 Aug;139:213041 DOI: 10.1016/j.bioadv.2022.213041.

Fakuade FE, Fauconnier J and Voigt N. Background calcium influx in arrhythmia: lead actor or extra? J Physiol. 2022, 10.1113/jp283032 DOI: 10.1113/jp283032.

Jung P, Seibertz F, Fakuade FE, Ignatyeva N, Sampathkumar S, Ritter M, Li H, Mason FE, Ebert A and Voigt N. Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy. Basic Res Cardiol. 2022 May 2;117:5 DOI: 10.1007/s00395-022-00912-z.

Liutkute A, Brundel BJ and Voigt N. Not the classical serendipity: does doxapram treat atrial fibrillation? Cardiovasc Res. 2022, 10.1093/cvr/cvac044 DOI: 10.1093/cvr/cvac044.

Shumanska M and Bogeski I. Redoxing PTPN22 activity. Elife. 2022;11 DOI: 10.7554/eLife.79125.

Jung P, Seibertz F, Fakuade FE, Ignatyeva N, Sampathkumar S, Ritter M, Li H, Mason FE, Ebert A and Voigt N. Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy. Basic Res Cardiol. 2022;117:5 DOI: 10.1007/s00395-022-00912-z.

 

Wagdi A, Malan D, Sathyanarayanan U, Beauchamp JS, Vogt M, Zipf D, Beiert T, Mansuroglu B, Dusend V, Meininghaus M, Schneider L, Kalthof B, Wiegert JS, König GM, Kostenis E, Patejdl R, Sasse P and Bruegmann T. Selective optogenetic control of G(q) signaling using human Neuropsin. Nat Commun. 2022;13:1765 DOI: 10.1038/s41467-022-29265-w.

 

Brandenburg S, Pawlowitz J, Steckmeister V, Subramanian H, Uhlenkamp D, Scardigli M, Mushtaq M, Amlaz SI, Kohl T, Wegener JW, Arvanitis DA, Sanoudou D, Sacconi L, Hasenfuß G, Voigt N, Nikolaev VO and Lehnart SE. A junctional cAMP compartment regulates rapid Ca(2+) signaling in atrial myocytes. J Mol Cell Cardiol. 2022;165:141-157 DOI: 10.1016/j.yjmcc.2022.01.003.

 

Maurer W, Hartmann N, Argyriou L, Sossalla S and Streckfuss-Bömeke K. Generation of homozygous Na(v)1.8 knock-out iPSC lines by CRISPR Cas9 genome editing to investigate a potential new antiarrhythmic strategy. Stem Cell Res. 2022;60:102677 DOI: 10.1016/j.scr.2022.102677.

 

Peris-Yagüe V, Rubio T, Fakuade FE, Voigt N, Luther S and Majumder R. A Mathematical Model for Electrical Activity in Pig Atrial Tissue. Front Physiol. 2022;13:812535 DOI: 10.3389/fphys.2022.812535.

 

Haupt LP, Rebs S, Maurer W, Hübscher D, Tiburcy M, Pabel S, Maus A, Köhne S, Tappu R, Haas J, Li Y, Sasse A, Santos CCX, Dressel R, Wojnowski L, Bunt G, Möbius W, Shah AM, Meder B, Wollnik B, Sossalla S, Hasenfuss G and Streckfuss-Bömeke K. Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients. Basic Res Cardiol. 2022;117:13 DOI: 10.1007/s00395-022-00918-7.

 

Tiburcy M, Meyer T, Satin PL and Zimmermann WH. Defined Engineered Human Myocardium for Disease Modeling, Drug Screening, and Heart Repair. Methods Mol Biol. 2022;2485:213-225 DOI: 10.1007/978-1-0716-2261-2_14.

 

2021

Wu H, Brand B, Eckstein M, Hochrein SM, Shumanska M, Dudek J, Nickel A, Maack C, Bogeski I and Vaeth M. Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo. Front Pharmacol. 2021;12:734078 DOI: 10.3389/fphar.2021.734078.

 

Bengel P, Dybkova N, Tirilomis P, Ahmad S, Hartmann N, B AM, Krekeler MC, Maurer W, Pabel S, Trum M, Mustroph J, Gummert J, Milting H, Wagner S, Ljubojevic-Holzer S, Toischer K, Maier LS, Hasenfuss G, Streckfuss-Bömeke K and Sossalla S. Detrimental proarrhythmogenic interaction of Ca(2+)/calmodulin-dependent protein kinase II and Na(V)1.8 in heart failure. Nat Commun. 2021;12:6586 DOI: 10.1038/s41467-021-26690-1.

 

Santos GL, Meyer T, Tiburcy M, DeGrave A, Zimmermann WH and Lutz S. Fibroblast Derived Human Engineered Connective Tissue for Screening Applications. J Vis Exp. 2021, 10.3791/62700 DOI: 10.3791/62700.

 

Menon PR, Doudin A, Gregus A, Wirths O, Staab J and Meyer T. The anti-parallel dimer binding interface in STAT3 transcription factor is required for the inactivation of cytokine-mediated signal transduction. Biochim Biophys Acta Mol Cell Res. 2021, 10.1016/j.bbamcr.2021.119118:119118 DOI: 10.1016/j.bbamcr.2021.119118.

 

Elkenani M, Nyamsuren G, Toischer K, Adham IM and Mohamed BA. Perturbed differentiation of murine embryonic stem cells upon Pelota deletion due to dysregulated FOXO1/β-catenin signaling. Febs j. 2021;288:3317-3329 DOI: 10.1111/febs.15643.

 

Mustroph J, Sag CM, Bähr F, Schmidtmann AL, Gupta SN, Dietz A, Islam MMT, Lücht C, Beuthner BE, Pabel S, Baier MJ, El-Armouche A, Sossalla S, Anderson ME, Möllmann J, Lehrke M, Marx N, Mohler PJ, Bers DM, Unsöld B, He T, Dewenter M, Backs J, Maier LS and Wagner S. Loss of CASK Accelerates Heart Failure Development. Circ Res. 2021;128:1139-1155 DOI: 10.1161/circresaha.120.318170.

Fakuade, F.E., Steckmeister, V., Seibertz, F., Gronwald, J., Kestel, S., Menzel, J., Pronto, J.R.D., Taha, K., Haghighi, F., Kensah, G., Pearman, C.M., Wiedmann, F., Teske, A.J., Schmidt, C., Dibb, K.M., El-Essawi, A., Danner, B.C., Baraki, H.,, Schwappach, B., Kutschka, I., Mason, F.E., Voigt, N., Altered Atrial Cytosolic Calcium Handling Contributes to the Development of Postoperative Atrial Fibrillation. Cardiovasc Res. 2021 Jun 16;117(7):1790-1801. doi: 10.1093/cvr/cvaa162.

Vogt, M., Schulz, B., Wagdi, A., Lebert, J., van Belle, G.J., Christoph, J., Bruegmann, T., Patejdl, R. Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Theranostics 2021; 11(11):5569-5584. doi:10.7150/thno.53883.

Fakuade, F.E., Tomsits, P. and Voigt, N. Connexin hemichannels in atrial fibrillation: orphaned and irrelevant? Cardiovasc Res. 2021;117:4-6 doi: 10.1093/cvr/cvaa308.

Kittana, N., Assali, M., Zimmermann, W.-H., Liaw, N., Santos, G.L., Rehmann, A., Lutz, S. Modulating the Biomechanical Properties of Engineered Connective Tissues by Chitosan-Coated Multiwall Carbon Nanotubes. Int J Nanomedicine. 2021 Feb 15;16:989-1000. doi: 10.2147/IJN.S289107. eCollection 2021.

Jatho, A., Zieseniss, A., Brechtel-Curth, K., Yamamoto, A., Coleman, M.L., Vergel Leon, A.M., Biggs, D., Davies, B., Pugh, C.W., Ratcliffe, P.J., Katschinski, D.M. Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia. Circ Res. 2021 Feb 25. doi: 10.1161/CIRCRESAHA.120.318216. Online ahead of print.

Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J.R., Sutanto, H., Pacheu, Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuβ, G., Gotthardt, M., Rog-Zielinska, E.A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J.W., Heijman, J., Voigt, N., Cyganek, L., Lenz, C., Lehnart, S.E. Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Circ Res. 2021 Jan 25. doi: 10.1161/CIRCRESAHA.119.316547. Online ahead of print.

Schnelle, M., Sawyer, I., Anilkumar, N., Mohamed, B.A., Richards, D.A., Toischer, K., Zhang, M., Catibog, N., Sawyer, G., Mongue-Din, H., Schröder, K., Hasenfuss, G. and Shah, A.M. NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload. Cardiovasc Res. 2021 Jan 1;117:178-187 doi: 10.1093/cvr/cvz331.

2020

Trum M, Islam MMT, Lebek S, Baier M, Hegner P, Eaton P, Maier LS and Wagner S. Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart. Am J Physiol Heart Circ Physiol. 2020;319:H1347-h1357 DOI: 10.1152/ajpheart.00182.2020.

Mason, F.E., Pronto, J.R.D., Alhussini, K., Maack, C., Voigt, N . Cellular and mitochondrial mechanisms of atrial fibrillation. Basic Res Cardiol. 2020 Nov 30;115(6):72. doi: 10.1007/s00395-020-00827-7.

Levent E, Noack C, Zelarayán LC, Katschinski DM, Zimmermann WH and Tiburcy M. Inhibition of Prolyl-Hydroxylase Domain Enzymes Protects From Reoxygenation Injury in Engineered Human Myocardium. Circulation. 2020;142:1694-1696 DOI: 10.1161/circulationaha.119.044471.

Gibhardt, D.S., Cappello, S., Bhardwaj, R., Schober, R., Kirsch, S.A., Bonilla del Rio, Z., Gahbauer, S., Bochiccio, A., Shumanska, M., Ickes, C., Stejerean-Todoran, I., Mitkovski, M., Alansary, D., Zhang, X., Revazian, A., Fahrner, M., Lunz, V., Frischauf, I., Luo, T., Ezerina, D., Messens, J., Belousov, V.V., Hoth, M., Böckmann, R.A., Hediger, M.A., Schindl, R., Bogeski, I. Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry. Cell Rep. 2020 Oct 20;33(3):108292. doi:10.1016/j.celrep.2020.108292.

Beretta, M., Santos, C.X.C., Molenaar, C., Hafstad, A.D., Miller, C.C., Revazian, A., Betteridge, K., Schröder, K., Streckfuß-Bömeke, K., Doroshow, J.H., Fleck, R.A., Su, T.-P., Belousov, V.V., Parsons, M., Shah, A.M. Nox4 regulates InsP ₃ receptor-dependent Ca ²⁺ release into mitochondria to promote cell survival. EMBO J 2020 Oct 1;39(19):e103530. doi: 10.15252/embj.2019103530. Epub 2020 Aug 10.

Crestani, T., Steichen, C., Neri, E., Rodrigues, M., Fonseca-Alaniz, M.H., Ormrod, B., Holt, M.R., Pandey, P., Harding, S., Ehler, E., Krieger, J.E. Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells. Biochem Biophys Res Commun. 2020 Sep 19;S0006-291X(20)31760-5.  doi: 10.1016/j.bbrc.2020.09.021. Online ahead of print.

Menzel, J., Kownatzki-Danger, D., Tokar, S., Ballone, A., Unthan-Fechner, K., Kilisch, M., Lenz, C., Urlaub, H., Mori, M., Ottmann, C., Shattock, M.J., Lehnart, S.E., Schwappach, B. 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban. Sci Signal. 2020 Sep 1;13(647):eaaz1436.

Campbell, H., Quick, A.P., Abu-Taha, I., Chiang, D.Y., Kramm, C.F., Word, T.A., Brandenburg, S., Hulskar, M., Alsina, K.M., Liu. H.-B., Martin, B., Uhlenkamp, D., Moore, O.M., Lahiri, S.K., Corradini, E., Kamler, M., Heck, A.J.R., Lehnart, S.E., Dobrev, D., Wehrens, X.H. T. Loss of SPEG Inhibitory Phosphorylation of RyR2 Promotes Atrial Fibrillation. Circulation. 2020 Jul 20. doi: 10.1161/CIRCULATIONAHA.120.045791. Online ahead of print.

Schnelle, M., Chong, M., Zoccarato, A., Elkenani, M., Sawyer, G.J., Hasenfuss, G., Ludwig, C., Shah, A.M. In vivo [U- ¹³ C]-glucose labeling to assess heart metabolism in murine models of pressure and volume overload. Am J Physiol Heart Circ Physiol. 2020 Jul 10. doi: 10.1152/ajpheart.00219.2020. Online ahead of print.

Hofhuis, J., Bersch, K., Wagner, S., Molina, C., Fakuade, F.E., Iyer, L.M., Streckfuß-Bömeke K., Toischer, K., Zelarayán, L.C., Voigt, N., Nikolaev, V.O., Maier, L.S., Klinge, L., Thoms, S. Dysferlin Links Excitation-Contraction Coupling to Structure and Maintenance of the Cardiac Transverse-Axial Tubule System. Europace. 2020 Jun 23;euaa093. doi: 10.1093/europace/euaa093. Online ahead of print.

Gundelach, L.A., Hüser, M.A., Beutner, D., Ruther, P., Bruegmann, T. Towards the Clinical Translation of Optogenetic Skeletal Muscle Stimulation. Pflugers Arch. 2020 May;472(5):527-545. doi: 10.1007/s00424-020-02387-0. Epub 2020 May 15.

Hübscher, D., Rebs, S., Maurer, W., Ghadri, J.R., Dressel, R., Templin, C., Streckfuss-Bömeke, K. Generation of iPSC-lines from two independent Takotsubo syndrome patients with recurrent Takotsubo events. Stem Cell Res. 2020 Apr;44:101746. doi: 10.1016/j.scr.2020.101746. Epub 2020 Feb 24.

Wilhelmi, T., Xu, X., Tan, X., Hulshoff, M.S., Maarmari, S., Sossalla, S., Zeisberg, M., Zeisberg, E.M. Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1. Theranostics. 2020 Mar 4;10(9):3905-3924. doi: 10.7150/thno.38640. eCollection 2020.

Kadjeh, S., Hindmarsh, V., Weber, F., Cyganek, L., Vidal, R.O., Torkieh, S., Streckfuss-Bömeke, K., Lbik, D., Tiburcy, M., Mohamed, B.A., Bonn, S., Toischer, K., Hasenfuss, G. CRISPLD1: a novel conserved target in the transition to human heart failure. Basic Res Cardiol. 2020 Mar 7;115(3):27.

Pak, V.V., Ezerina, D., Lyublinskaya, O.G., Pedre, B., Tyurin-Kuzmin, P.A., Mishina, N.M., Thauvin, M., Young, D., Wahni, K., Martinez Gache, S.A., Demidovich, A.D., Ermakova, Y.G., Maslova, Y.D., Shokhina, A.G., Eroglu, E., Bilan, D.S., Bogeski, I., Michel, T., Vriz, S., Messens, J., Belousov, V.V. Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function. Cell Metab. 2020 Mar 3;31(3):642-653.e6.

2019     

Leinhos, L., Peters, J., Krull, S., Helbig, L., Vogler, M., Levay, M., van Belle, G.J., Ridley, A.J., Lutz, S., Katschinski, D.M., Zieseniss, A. Hypoxia suppresses myofibroblast differentiation by changing RhoA activity. J Cell Sci. 2019 Feb 18;132(5). pii: jcs223230.

Dworatzek, E., Mahmoodzadeh, S., Schriever, C. Kusumoto, K., Kramer, L., Santos, G., Fliegner, D., Leung, Y.K., Ho, S.M., Zimmermann, W.H., Lutz, S., Regitz-Zagrosek, V. Sex-specific regulation of collagen I and III   expression by 17β-Estradiol in cardiac fibroblasts: role of estrogen receptors. Cardiovasc Res. 2019 Feb 1;115(2):315-327.

2018

Bastug-Özel, Z., Wright, P.T., Kraft, A.E., Pavlovic, D., Howie, J., Froese, A., Fuller, W., Gorelik, J., Shattock, M.J., Nikolaev, V.O. Heart failure leads to altered β2-adrenoceptor/cAMP dynamics in the sarcolemmal phospholemman/Na, K ATPase microdomain: Bastug et al. Phospholemman cAMP microdomain. Cardiovasc. Res. 2018 Aug 27. doi: 10.1093/cvr/cvy221. [Epub ahead of print].

Sing, S., Lämmle. S., Giese, H., Kämmerer, S., Meyer-Roxlau, S., Alfar, E.A., Dihazi, H., Guan, K., El-Armouche, A. Richter, F. The reduced activity of PP-1 α under redox stress condition is a consequence of GSH-mediated transient disulfide formation. Sci Rep. 2018 Dec 7;8(1):17711.

Doudin, A., Becker, A., Rothenberger, A., Meyer, T. The associations between serum 25-hydroxyvitamin D and red blood cell indices reported from the KiGGS study are, except for mean corpuscular hemoglobin, not mediated by health-related quality of life. Eur J Pediatr. 2018 Nov;177(11):1733-1734.

Hulshoff, M.S., Rath, S.K., Xu, X., Zeisberg, M., Zeisberg, E.M. Causal Connections From Chronic Kidney Disease to Cardiac Fibrosis. Semin Nephrol. 2018 Nov;38(6):629-636.

 

Brandenburg, S., Pawlowitz, J., Fakuade, F.E., Kownatzki-Danger, D., Kohl, T., Mitronova, G.Y., Scardilgi, M., Neef, J., Schmidt, C., Wiedmann, F., Pavone, F.S., Sacconi, L., Kutschka, I., Sossalla, S., Moser, T., Voigt, N., Lehnart, S.E. Axial Tubule Junctions Activate Atrial C²⁺ Release Across Species. Front Physiol. 2018 Oct 8;9:1227. doi: 10.3389/fphys.2018.01227. eCollection 2018.

Swain. L., Nanadikar, M.S., Borowik, S. Zieseniss, A., Katschinski, D.M. Transgenic organisms meet redox bioimaging: one step closer to physiology. Antioxid Redox Signal 2018 Aug 20;29(6):603-612. doi: 10.1089/ars.2017.7469. Epub 2018 Feb 16.

Emmerson, A., Trevelin, S.C. , Monque-Din, H., Becker, P.D., Ortiz, C., Smyth, L.A., Peng, Q., Elqueta, R., Sawyer, G., Ivetic, A., Lechler, R. I., Lombardi, G., Shah, A.M. Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodelling. J Clin Invest. 2018 Jul 2;128(7):3088-3101. doi: 10.1172/JCI97490. Epub 2018 Jun 11.

Doudin, A., Becker, A., Rothenberger, A., Meyer, T. Relationship between serum 25-hydroxyvitamin D and red blood cell indices in German asolescents. EUR J Pediatr. 2018 Apr;177(4):583-591. doi:10.1007/s00431-018-3092-3. Epub 2018 Jan 31.

Ranieri, A., Kemp, E., Burgoyne, J.R., Avkiran, M. β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573. J Mol Cell Cardiol. 2018 Feb;115:20-31. doi: 10.1016/j.yjmcc.2017.12.016. Epub 2017 Dec 30.

2017

Thapa, D., Nichols, C., Bassi, R., Martin, E.D., Verma, S., Conte, M.R., De Santis, V., De Nicola, G.F., Marber, M.S. TAB1-induced auto-activation of p38α mitogen-activated protein kinase is crucially dependent on Threonine 185. Mol Cell Biol. 2017 Dec 11. pii: MCB.00409-17. doi: 10.1128/MCB.00409-17. [Epub ahead of print].

Pan, Y., Thapa, D., Baldissera, L. Jr., Argunhan, F., Aubdool, A.A., Brain, S.D. Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature. Pflugers Arch. 2017 Nov 21. doi: 10.1007/s00424-017-2085-9. [Epub ahead of print] Review.

Sağ, C.M., Schnelle, M., Shah, A.M. Response by Sag et al to Letter Regarding Article, "Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure". Circulation. 2017 Nov 21;136(21):2090-2091. No abstract available.

Perera, R.K., Fischer, T.H., Wagner, M., Dewenter, M., Vettel, C., Bork, N.I., Maier, L.S., Conti, M., Wess, J., El-Armouche, A., Hasenfuß, G., Nikolaev, V.O. Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4. Sci Rep. 2017 Nov 9;7(1):15222.

Sag, C.M., Schnelle, M., Shah, A.M. Response by Sag et al to Letter Regarding Article, "Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure". Circulation. 2017 Nov 21;136(21):2090-2091. doi: 10.1161/CIRCULATIONAHA.117.030515.

Schnelle, M., Catibog, N., Zhang, M., Nabeebaccus, A.A., Anderson, G., Richards, D.A., Sawyer, G., Zhang, X., Toischer, K., Hasenfuss, G., Monaghan, M.J., Shah, A.M. Echocardiographic evaluation of diastolic function in mouse models of heart disease. J Mol Cell Cardiol. 2017 Oct 19;114:20-28. doi: 10.1016/j.yjmcc.2017.10.006. [Epub ahead of print].

Wottawa, M., Naas, S., Böttger, J., van Belle, G.J., Möbius, W., Revelo, N.H., Heidenreich, D., von Ahlen, M., Zieseniss, A., Kröhnert, K., Lutz, S., Lenz, C., Urlaub, H., Rizzoli, S.O., Katschinski, D.M. Hypoxia-stimulated membrane trafficking requires T-Plastin. Acta Physiol (Oxf). 2017 Sep;221(1):59-73.

Beneke, A., Guentsch, A., Hillemann, A., Zieseniss, A., Swain, L., Katschinski, D.M. Loss of PHD3 in myeloid cells dampens the inflammatory response and fibrosis after hind-limb ischemia. Cell Death Dis. 2017 Aug 10;8(8):e2976.

Aubdool, A.A., Thakore, P., Argunhan, F., Smillie, S.J., Schnelle, M., Srivastava, S., Alawi, K.M., Wilde, E., Mitchell, J., Farrell-Dillon, K., Richards, D.A., Maltese, G., Siow, R.C., Nandi, M., Clark, J.E., Shah, A.M., Sams, A., Brain, S.D. A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure. Circulation. 2017 Jul 25;136(4):367-383. doi: 10.1161/CIRCULATIONAHA.117.028388. Epub 2017 Apr 26.

Sag, C.M., Schnelle, M., Zhang, J., Murdoch, C.E., Kossmann, S., Protti, A., Santos, C.X.C., Sawyer, G., Zhang, X., Mongue-Din, H., Richards, D.A., Brewer, A.C., Prysyazhna, O., Maier, L.S., Wenzel, P., Eaton, P.J., Shah, A.M.. Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure. Circulation. 2017 May 30;135(22):2163-2177. doi: 10.1161/CIRCULATIONAHA.116.023877. Epub 2017 Mar 15.

Weeks, K.L., Ranieri, A., Karaś, A., Bernardo, B.C., Ashcroft, A.S., Molenaar, C., McMullen, J.R., Avkiran, M. β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation. J Am Heart Assoc. 2017 Mar 25;6(4). pii: e004861. doi: 10.1161/JAHA.116.004861.

Tiburcy, M., Hudson, J.E., Balfanz, P., Schlick, S., Meyer, T., Chang Liao, M.L., Levent, E., Raad, F., Zeidler, S., Wingender, E., Riegler, J., Wang, M., Gold, J.D., Kehat, I., Wettwer, E., Ravens, U., Dierickx, P., van Laake, L.W., Goumans, M.J., Khadjeh, S., Toischer, K., Hasenfuss, G., Couture, L.A., Unger, A., Linke, W.A., Araki, T., Neel, B., Keller, G., Gepstein, L., Wu, J.C., Zimmermann, WH. Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair. Circulation. 2017 May 9;135(19):1832-1847. doi: 10.1161/CIRCULATIONAHA.116.024145. Epub 2017 Feb 6.

Guentsch, A., Beneke, A., Swain, L., Farhat, K., Nagarajan, S., Wielockx, B., Raithatha, K., Dudek, J., Rehling, P., Zieseniss, A., Jatho, A., Chong, M., Santos, C.X., Shah, A.M., Katschinski, D.M. PHD2 is a regulator for gly-colytic reprogramming in macrophages. Mol Cell Biol. 2016 Dec 19;37(1). pii: e00236-16. Print 2017 Jan 1.

2016

Liu, X., Qi, J., Xu, X., Zeisberg, M., Guan, K., Zeisberg, E.M. Differentiation of functional endothelial cells from human induced pluripotent stem cells: A novel, highly efficient and cost effective method. Differentiation. 2016 Oct - Nov;92(4):225-236. doi: 10.1016/j.diff.2016.05.004. Epub 2016 Jun 4.

Swain, L., Kesemeyer, A., Meyer-Roxlau, S., Vettel, C., Zieseniss, A., Güntsch, A., Jatho, A., Becker, A., Nanadikar, M.S., Morgan, B., Dennerlein, S., Shah, A.M., El-Armouche, A., Nikolaev, V.O., Katschinski, D.M. Redox Imaging Using Cardiac Myocyte Specific Transgenic Biosensor Mice. Circ Res. 2016 Oct 14;119(9):1004-1016.

Sirker, A., Murdoch, C.E., Protti, A., Sawyer, G.J., Santos, C.X., Martin, D., Zhang, X., Brewer, A.C., Zhang, M., Shah, A.M. Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction. J Mol Cell Cardiol. 2016 Sep;98:11-17.

Puhl, S.L., Weeks, K.L., Ranieri, A., Avkiran, M. Assessing structural and functional responses of murine hearts to acute and sustained β-adrenergic stimulation in vivo. J Pharmacol Toxicol Methods. 2016 May-Jun;79:60-71.

Mohamed, B.A., Asif, A.R., Schnelle, M., Qasim, M., Khadjeh, S., Lbik, D., Schott, P., Hasenfuss, G., Toischer, K. Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy. J Transl Med. 2016 May 27; 14(1):149.

Santos, C.X., Raza, S., Shah, A.M. Redox signaling in the cardiomyocyte: From physiology to failure. Int J Biochem Cell Biol. 2016 May;74:145-51.

Hoogewijs, D., Vogler, M., Zwenger, E., Krull, S., Zieseniss, A. Oxygen-dependent regulation of aquaporin-3 expression. Hypoxia (Auckl). 2016 Apr 21;4:91-97.

Mohamed, B.A., Schnelle, M., Khadjeh, S., Lbik, D., Herwig, M., Linke, W.A., Hasenfuss, G., Toischer, K. Molecular and structural transition mechanisms in long-term volume overload. Eur J Heart Fail. 2016 Apr; 18(4):362-71.

Mistry, R.K., Murray, T.V., Prysyazhna, O., Martin, D., Burgoyne, J.R., Santos, C., Eaton, P., Shah, A.M., Brewer, A.C. Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling. J Biol Chem. 2016 Jan 22;291(4):1774-88.

Korthout, T., Emanuelli, G., Hutchins, J.R. Extracting order from heterogeneity: A report on the EpiGeneSys workshop "Single Cell Epigenetics" in Montpellier. June 11-12, 2015. Bioessays. 2016 Jan;38(1):4-7. doi: 10.1002/bies.201500160. Epub 2015 Nov 16.

Santos, C.X., Hafstad, A.D., Beretta, M., Zhang, M., Molenaar, C., Kopec, J., Fotinou, D., Murray, T.V., Cobb, A.M., Martin, D., Zeh Silva, M., Anilkumar, N., Schröder, K., Shanahan, C.M., Brewer, A.C., Brandes, R.P., Blanc, E., Parsons, M., Belousov, V., Cammack, R., Hider, R.C., Steiner, R.A., Shah, A.M. Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling. EMBO J. 2016 Feb 1;35(3):319-34.

Protti, A., Mongue-Din, H., Mylonas, K.J., Sirker, A., Sağ, C.M., Swim, M.M., Maier, L., Sawyer, G., Dong, X., Botnar, R., Salisbury, J., Gray, G.A., Shah, A.M. Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction. J Mol Cell Cardiol. 2016 Jan;90:120-8.

2015

Siegert, I., Schödel, J., Nairz, M., Schatz, V., Dettmer, K., Dick, C., Kalucka, J., Franke, K., Ehrenschwender, M., Schley, G., Beneke, A., Sutter, J., Moll, M., Hellerbrand, C., Wielockx, B., Katschinski, D.M., Lang, R., Galy, B., Hentze, M.W., Koivunen, P., Oefner, P.J., Bogdan, C., Weiss, G., Willam, C., Jantsch, J. Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen. Cell Rep. 2015 Dec 15; 13(10), 2048-2055.

Hartmann, S., Ridley, A.J., Lutz, S. The function of Rho-dependent kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease Front. Pharmacol. 2015 Nov 20;6:276.

Staab, J., Riebeling, T., Koch, V., Herrmann-Lingen, C., Meyer, T. The two interfaces of the STAT1 N-terminus exhibit opposite functions in IFNγ-regulated gene expression. Mol Immunol. 2015 Oct;67(2 Pt B):596-606.

Jatho, A., Hartmann, S., Kittana, N., Mügge, F., Wuertz, C.M., Tiburcy, M., Zimmermann, W.-H., Katschinski, D.M., Lutz, S. RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes. PLoS One. 2015 Oct 8;10(10):e0137519.

Vogler, M., Zieseniss, A., Hesse, A.R., Levent, E., Tiburcy, M., Heinze, E., Burzlaff, N., Schley, G., Eckardt, K.U., Willam, C., Katschinski, D.M. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch. 2015 Oct;467(10):2141-9.

Ongherth, A., Pasch, S., Wuertz, C.M., Nowak K., Kittana, N., Weis, C.A., Jatho, A., Vettel, C., Tiburcy, M., Toischer, K., Hasenfuss, G., Zimmermann, W.-H., Wieland, T., Lutz, S. p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. J Mol Cell Cardiol. 2015 Sep 21;88:39-54.

Johnston, A.S., Lehnart, S.E., Burgoyne, J.R. Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII. Front Pharmacol. 2015 Aug 10;6:166.

Czepluch, F.S., Vogler, M., Kuschicke, H., Meier, J., Gogiraju, R., Katschinski, D.M., Riggert, J., Hasenfuss, G., Schäfer, K. Circulating endothelial cells expressing the angiogenic transcription factor Krüppel-like factor 4 are decreased in patients with coronary artery disease. Microcirculation. 2015 Nov;22(8):700-10.

Zhang, M., Prosser, B.L., Bamboye, M.A., Gondim, A.N., Santos, C.X., Martin, D., Ghigo, A., Perino, A., Brewer, A.C., Ward, C.W., Hirsch, E., Lederer, W.J., Shah, A.M. Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation. J Am Coll Cardiol. 2015 Jul 21;66(3):261-72.

Xu, X., Tan, X., Tampe, B., Sanchez, E., Zeisberg, M., Zeisberg, E.M. Snail is a Direct Target of HIF1α in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells. J Biol Chem. 2015 Jul 3;290(27):16653-64.

Fischer, T.H., Herting, J., Mason, F.E., Hartmann, N., Watanabe, S., Nikolaev, V.O., Sprenger, J.U., Fan, P., Yao, L., Popov, A.F., Danner, B.C., Schöndube, F., Belardinelli, L., Hasenfuss, G., Maier, L.S., Sossalla, S. Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII. Cardiovasc Res. 2015 Jul 1;107(1):184-96.

Book chapter: Bastuğ, Z., Nikolaev, V.O. Cyclic Nucleotide Signaling (Methods in Signal Transduction Series) edited by Xiaodong Cheng., May 12, 2015 by CRC Press. ISBN 9781482235562.

Sprenger. J.U., Perera, R.K., Steinbrecher, J.H., Lehnart, S.E., Maier, L.S., Hasenfuss, G., Nikolaev, V.O. In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease. Nat Commun. 2015 Apr 28;6:6965.

Perera, R.K., Sprenger, J.U., Steinbrecher, J.H., Hübscher, D., Lehnart, S.E., Abesser, M., Schuh, K., El-Armouche, A., Nikolaev, V.O. Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy. Circ Res. 2015 Apr 10;116(8):1304-11.

Murray, T.V., Smyrnias, I., Schnelle, M., Mistry, R.K., Zhang, M., Beretta, M., Martin, D., Anilkumar, N., de Silva, S.M., Shah, A.M., Brewer, A.C. Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription. J Mol Cell Cardiol. 2015 Feb;79:54-68.

2014

Riebeling, T., Staab, J., Herrmann-Lingen, C., Meyer, T. DNA binding reduces the dissociation rate of STAT1 dimers and impairs the interdimeric exchange of protomers. BMC Biochem. 2014 Dec 20;15:28.

Izarra, A., Moscoso, I., Levent, E., Cañón, S., Cerrada, I., Díez-Juan, A., Blanca, V., Núñez-Gil, I.J., Valiente, I., Ruíz-Sauri, A., Sepúlveda, P., Tiburcy, M., Zimmermann, W.-H., Bernad, A. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction. Stem Cell Reports. 2014 Dec 9;3(6):1029-42.

Sağ, C.M., Mallwitz, A., Wagner, S., Hartmann, N., Schotola, H., Fischer, T.H., Ungeheuer, N., Herting, J., Shah, A.M., Maier, L.S., Sossalla, S., Unsöld, B. Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner. J Mol Cell Cardiol. 2014 Nov; 76:94-105.

Wagner, S., Dantz, C., Flebbe, H., Azizian, A., Sağ, C.M., Engels, S., Möllencamp, J., Dybkova, N., Islam, T., Shah, A.M., Maier, L.S. NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII. J Mol Cell Cardiol. 2014 Oct;75:206-15.

Swain, L., Wottawa, M., Hillemann, A., Beneke, A., Odagiri, H., Terada, K., Endo, M., Oike, Y., Farhat, K., Katschinski, D.M. Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions. J Leukoc Biol. 2014 Sep;96(3):365-75.

Sağ, C.M., Santos, C.X., Shah, A.M. Redox regulation of cardiac hypertrophy. J Mol Cell Cardiol. 2014 Aug;73:103-11.

Nussbeck, S.Y., Weil, P., Menzel, J., Marzec, B., Lorberg, K., Schwappach, B. The laboratory notebook in the 21st century: The electronic laboratory notebook would enhance good scientific practice and increase research productivity. EMBO Rep. 2014 Jun;15(6):631-4.

Puente, B.N., Kimura, W., Muralidhar, S.A., Moon, J., Amatruda, J.F., Phelps, K.L., Grinsfelder, D., Rothermel, B.A., Chen, R., Garcia, J.A., Santos, C.X., Thet, S., Mori, E., Kinter, M.T., Rindler, P.M., Zacchigna, S., Mukherjee, S., Chen, D.J., Mahmoud, A.I., Giacca, M., Rabinovitch, P.S., Aroumougame, A., Shah, A.M., Szweda, L.I., Sadek, H.A. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014 Apr 24;157(3):565-79.

Vettel C., Lämmle, S., Ewens, S., Cervirgen, C., Emons, J., Ongherth, A., Dewenter, M., Lindner, D., Westermann, D., Nikolaev, V.O., Lutz, S., Zimmermann, W.-H., El-Armouche, A. PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1246-52.

Götz, K.R., Sprenger, J.U., Perera, R.K., Steinbrecher, J.H., Lehnart, S.E., Kuhn, M., Gorelik, J., Balligand, J.L., Nikolaev, V.O. Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes. Circ Res. 2014 Apr 11;114(8):1235-45.

Koch, R., Demant, M., Aung, T., Diering, N., Cicholas, A., Chapuy, B., Wenzel, D., Lahmann, M., Güntsch, A., Kiecke, C., Becker, S., Hupfeld, T., Venkataramani, V., Ziepert, M., Opitz, L., Klapper, W., Trümper, L., Wulf, G.G. Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma. Blood. 2014 Apr 3;123(14):2189-98.

Weber, M., Heta, E., Moreira, R., Gesche, V.N.,Schermer, T., Frese, J., Jockenhoevel, S., Mela, P. Tissue-engineered fibrin-based heart valve with a tubular leaflet design. Tissue Eng Part C Methods. 2014 Apr;20(4):265-75.

Longman, M.R., Ranieri, A., Avkiran, M., Snabaitis A.K. Regulation of PP2AC Carboxylmethylation and Cellular Localisation by Inhibitory Class G-Protein Coupled Receptors In Cardiomyocytes. PLoS One. 2014 Jan 27;9(1):e86234.

Santos, C.X., Nabeebaccus, A.A., Shah, A.M., Camargo, L.L., Filho, S.V., Lopes, L.R. Endoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: potential role in hypertension. Antioxid Redox Signal. 2014 Jan 1;20(1):121-34. doi: 10.1089/ars.2013.5262. Epub 2013 May 1.

Hesse, A.R., Levent, E., Zieseniss, A., Tiburcy, M., Zimmermann, W.-H., Katschinski, D.M. Lights on for HIF-1α: genetically enhanced mouse cardiomyocytes for heart tissue imaging. Cell Physiol Biochem. 2014;34(2):455-62.

2013

Burgoyne, J.R., Oviosu, O., Eaton, P. The PEG-switch assay: a fast semi-quantitative method to determine protein reversible cysteine oxidation. J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):297-301.

Sağ, C.M., Wolff, H.A., Neumann, K., Opiela, M.K., Zhang, J., Steuer, F., Sowa, T., Gupta, S., Schirmer, M., Hünlich, M., Rave-Fränk, M., Hess, C.F., Anderson, M.E., Shah, A.M., Christiansen, H., Maier, L.S. Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII. Basic Res Cardiol. 2013 Nov;108(6):385.

Abonnenc, M., Nabeebaccus, A.A., Mayr, U., Barallobre-Barreiro, J., Dong, X., Cuello, F., Sur, S., Drozdov, I., Langley, S.R., Lu, R., Stathopoulou, K., Didangelos, A., Yin, X., Zimmermann, W.-H., Shah, A.M., Zampetaki, A., Mayr, M. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ Res. 2013 Oct 25;113(10):1138-47.

Toischer, K. Hartmann, N. Wagner, S. Fischer, TH. Herting, J. Danner, BC. Sağ, C.M., Hund, TJ. Mohler, PJ. Belardinelli, L. Hasenfuss, G. Maier, LS. Sossalla, S. Role of late sodium current as a potential arrhythmo-genic mechanism in the progression of pressure-induced heart disease.    J Mol Cell Cardiol. 2013 Aug;61:111-22. doi: 10.1016/j.yjmcc.2013.03.021. Epub 2013 Apr 6.

Vogler, M., Vogel, S., Krull, S., Farhat, K., Leisering, P., Lutz, S., Wuertz, C.M., Katschinski, D.M., Zieseniss, A. Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution. PLoS One. 2013 Jul 18;8(7):e69128.doi: 10.1371/journal.pone.0069128. Print 2013.

Wottawa, M., Leisering, P., Ahlen, M v., Schnelle, M., Vogel, S., Malz, C., Bordoli, M.R., Camenisch, G., Hesse, A., Napp, J., Alves, F., Kristiansen, G., Farhat, K., Katschinski, D.M. Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processing. Int J Cancer. 2013 Jun 15;132(12):2787-98.

Neef, S., Sağ, C.M., Daut, M., Bäumer, H., Grefe, C., El-Armouche, A., DeSantiago, J., Pereira, L., Bers, D.M., Backs, J., Maier, L.S. While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice. J Mol Cell Cardiol. 2013 Jun;59:107-16.

Sukumar, P., Viswambharan, H., Imrie, H., Cubbon, R.M., Yuldasheva, N., Gage, M., Galloway, S., Skromna, A., Kandavelu, P., Santos, C.X., Gatenby, V.K., Smith, J., Beech, D.J., Wheatcroft, S.B., Channon, K.M., Shah, A.M., Kearney, M.T. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes. 2013 Jun;62(6):2130-4.

Karamariti, E., Margariti, A., Winkler, B., Wang, X., Hong, X., Baban, D., Ragoussis, J., Huang, Y., Han, J.D., Wong, M.M., Sağ, C.M., Shah, A.M., Hu, Y., Xu, Q. Smooth muscle cells differentiated from reprogrammed embryonic lung fibroblasts through DKK3 signaling are potent for tissue engineering of vascular grafts. Circ Res. 2013 May 24;112(11):1433-43.

Perera, R.K., Nikolaev, V.O. Compartmentation of cAMP signalling in cardiomyocytes in health and disease. Acta Physiol (Oxf). 2013 Apr;207(4):650-62.

Sprenger, J.U., Nikolaev, V.O. Biophysical techniques for detection of cAMP and cGMP in living cells. Int J Mol Sci. 2013 Apr 12;14(4):8025-46.

Anilkumar, N., San Jose, G., Sawyer, I., Santos, C.X., Sand, C., Brewer, A.C., Warren, D., Shah, A.M. A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):e104-12.

Avan, A., Quint, K., Nicolini, F., Funel, N., Frampton, A.E., Maftouh, M., Pelliccioni, S., Schuurhuis, G.J., Peters, G.J., Giovannetti, E. Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.